JMRI Letter from the Editor: June 2025

We all go down rabbit holes. Or at least I do.

After watching “A Complete Unknown,” the Bob Dylan biopic, I wiki’d Joan Baez (who had a surprisingly important supporting [in both definitions of the word] role in the film). Joan Baez was one of the more prominent singers of the late 60’s folk era. Her most well-known song was about Bob Dylan, named “Diamonds and Rust” (although I am partial to the Judas Priest version). Among the factoids I noted was that Joan Baez’s dad received a PhD from Stanford and had helped to invent the x-ray microscope. On the surface this might seem an odd combination of biographical trivia.

Many of you are too young to be familiar with the singer/actress Olivia Newton John (slightly more recent than Joan Baez), but her grandfather was a Nobel prize winner in physics, Max Born. The actor Willem Defoe (Mississippi Burning/John Wick/Spiderman) is a quite talented thespian. Interestingly, his brother helped to develop pancreatic transplantation. And Diana Ross’s (major Motown singer) sister, was not only the first African American women dean of any medical school-but did that three times.

Maybe these are random facts. Or maybe they show the intersection of science and creativity. Or rather the ying of science to the yang of innovation. Maybe the best of us, have a bit of both. Maybe all of us do-we just need to dig deep and find it.

Consider Brian May of Queen (not a fan of his music, but another pretty good biopic). Quite a talented guitarist, but he also obtained a PhD in Astrophysics from Imperial College. How about Dexter Holland from The Offspring (Kristy, are you doing okay?-their best and a rather touching song)? He is the group’s guitarist and lead singer, who also later earned a PhD in Molecular Biology, from USC. Although not PhDs, Tom Morello (Rage Against the Machine- Guerrilla Radio being their most ironically “pop” [but not best] song) and Rivers Cuomo (no relation to the politicians Mario and Andrew) of Weezer (Buddy Holly, or at least its clever video, reigns musically supreme) are Harvard graduates.

The science part is undoubtedly hard, taking years of intense education. Unfortunately, there seems to be no school for the creative part. Equally hard. Equally intense. Quite worthy of attention, but disproportionately hard to train.

Mark E. Schweitzer, MD

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Cover Image

Free Access

Assessment of Age‐Related Microstructure Changes in Thigh Skeletal Muscle Based on Neurite Orientation Dispersion and Density Imaging

Yiou Wang MS, Yiqiong Yang MS, Ziru Qiu MS, Yanjun Chen MD, PhD, Xinru Zhang MS, Qianyi Qiu MS, Yi Yang MS, Qinglin Xie MS, Xinyuan Zhang PhD, Xiaodong Zhang MD, PhD

Pages: spcone | First Published: 09 May 2025

DWI and Microstructure Parameters Mapping of the Thigh Skeletal Muscles of Three Volunteers from Different Age Groups. By Wang et al. (2601-2614)

Issue Information

Free Access

Issue Information

Pages: 2349-2354 | First Published: 09 May 2025

Review

Open Access

Fetal Cardiovascular Magnetic Resonance: History, Current Status, and Future Directions

Dominika Suchá MD, PhD, Anneloes E. Bohte MD, PhD, Pim van Ooij PhD, Tim Leiner MD, PhD, Eric M. Schrauben PhD, Heynric B. Grotenhuis MD, PhD

Pages: 2357-2375 | First Published: 23 November 2024

Computer‐Aided Detection (CADe) and Segmentation Methods for Breast Cancer Using Magnetic Resonance Imaging (MRI)

Payam Jannatdoust, Parya Valizadeh, Nikoo Saeedi, Gelareh Valizadeh, Hanieh Mobarak Salari, Hamidreza Saligheh Rad, Masoumeh Gity

Pages: 2376-2390 | First Published: 09 January 2025

Accuracy of MRI R2* Mapping in Diagnosis of Liver Iron Concentration: A Meta‐Analysis

Sue Cao MS, Xin Gao MS, Hua Wang PhD, Yaoping Chen MS, Jianbo Xu MS, Jie Zhang BS, Ruomi Guo PhD

Pages: 2391-2403 | First Published: 06 January 2025

Plain Language Summary

Although current guidelines recommend the quantification of the LIC with the R2* method, comprehensive evaluation of its diagnostic accuracy at clinically relevant thresholds remains necessary. This study aimed to assess the accuracy of the R2* method in measuring LIC through a meta-analysis. Twenty-six studies involving 1687 patients were included. The findings revealed that the R2* method demonstrated high accuracy (all sensitivities and specificities ≥ 0.93 and AUCs ≥ 0.96) in identifying patients with different clinically relevant LIC thresholds (1.8, 3.2, 7.0, and 15.0 mg/g). The results of this study provide a theoretical basis for the clinical application and wide dissemination of the R2* method.

Open Access

The Role of Proton Magnetic Resonance Spectroscopy in Neonatal and Fetal Brain Research

Steve C.N. Hui PhD, Nickie Andescavage MD, Catherine Limperopoulos PhD

Pages: 2404-2424 | First Published: 21 January 2025

Research Article

Pelvis

Open Access

Long‐Term Risk of Clinically Significant Prostate Cancer in Biopsy‐Negative Patients With Baseline Biparametric Prostate MRI

Laura Parhiala MD, Juha Knaapila MD, PhD, Ivan Jambor MD, PhD, Janne Verho MD, Kari Syvänen MD, PhD, Hannu Aronen MD, PhD, Peter Boström MD, PhD, Otto Ettala MD, PhD

Pages: 2425-2432 | First Published: 27 November 2024

Neuro

Open Access

Seizure Burden and Clinical Risk Factors in Glioma‐Related Epilepsy: Insights From MRI Voxel‐Based Lesion‐Symptom Mapping

Tianshi Li PhD, Qiuling Li MD, Xing Fan PhD, Lei Wang PhD, Gan You PhD

Pages: 2433-2443 | First Published: 15 November 2024

Neuro

Open Access

Improving the Detection of Myelin Integrity in Multiple Sclerosis Using Selective Inversion Recovery for MRI With Quantitative Magnetization Transfer

Ahmad A. Toubasi MD, Dhairya A. Lakhani MD, Gary Cutter PhD, Caroline Gheen BS, Taegan Vinarsky BS, Eric Brian BS, Joy Derwenskus DO, James E. Eaton MD, Richard D. Dortch PhD, Junzhong Xu PhD, Francesca Bagnato MD, PhD

Pages: 2444-2454 | First Published: 10 December 2024

Neuro

Application of Anti‐Motion Ultra‐Fast Quantitative MRI in Neurological Disorder Imaging: Insights From Huntington’s Disease

Fei Wu MD, Haiyang Luo MD, PhD, Xiao Wang MD, PhD, Qinqin Yang PhD, Yuchuan Zhuang PhD, Liangjie Lin PhD, Yanbo Dong PhD, Andrey Tulupov MD, PhD, Yong Zhang MD, PhD, Shuhui Cai PhD, Zhong Chen PhD, Congbo Cai PhD, Jianfeng Bao PhD, Jingliang Cheng MD, PhD

Pages: 2455-2468 | First Published: 29 January 2025

Open Access

Semi‐Supervised Learning Allows for Improved Segmentation With Reduced Annotations of Brain Metastases Using Multicenter MRI Data

Jon André Ottesen PhD, Elizabeth Tong MD, Kyrre Eeg Emblem PhD, Anna Latysheva MD, Greg Zaharchuk MD, PhD, Atle Bjørnerud PhD, Endre Grøvik PhD

Pages: 2469-2479 | First Published: 10 January 2025

Open Access

Diagnostic Accuracy of 1H‐MRS Using PRESS and MEGA‐PRESS Techniques in the Preoperative Grading of Patients With Gliomas

Maria L. Brun-Vergara MD, Gerd Melkus PhD, Santanu Chakraborty MD, MBBS, MRCP, DMRD, FRCR, FRCPC, Nader Zakhari MD, FRCPC, Carlos Torres MD, FRCPC, FCAR, Fahad AlKherayf MD, Leya Ghantous, Rebecca Thornhill PhD, John Woulfe MD, PhD, Gerard H. Jansen MD, Thanh B. Nguyen MD, FRCPC

Pages: 2480-2488 | First Published: 24 February 2025

Evaluation of Neurovascular Coupling in Early‐Onset and Late‐Onset Epilepsy of Unknown Etiology

Xinyue Wan PhD, Xuyang Yin PhD, Xinyi Chai MM, Mei Tian MD, PhD, Jianhong Wang MD, PhD, Jun Zhang MD, PhD

Pages: 2489-2500 | First Published: 13 December 2024

Editorial

Editorial for “Evaluation of Neurovascular Coupling in Early‐Onset and Late‐Onset Epilepsy of Unknown Etiology”

Thomas Welton PhD, Yee Leng Tan MD, Ling-Ling Chan FRCR

Pages: 2501-2502 | First Published: 03 January 2025

Commentary

Clinical Utility of DTI‐ALPS in Identifying Dysfunction in the “Glymphatic” System

Nivedita Agarwal MD

Pages: 2503-2504 | First Published: 24 December 2024

Research Article

Pediatrics

Open Access

Improving Image Quality and Decreasing SAR With High Dielectric Constant Pads in 3 T Fetal MRI

Zhengyang Zhu MD, Xunwen Xue MS, Tang Tang MS, Chao Luo PhD, Ye Li PhD, Jing Chen MS, Biyun Xu PhD, Zengping Lin MS, Xin Zhang MD, Zhengge Wang MD, Jun Chen PhD, Jiaming Lu MD, Wen Zhang MD, Xin Li MD, Qian Chen MD, Zhuoru Jiang MD, Junxia Wang MS, Qing Hu MS, Sven Haller MD, PhD, Ming Li MS, Chenchen Yan MD, Bing Zhang MD, PhD

Pages: 2505-2515 | First Published: 21 January 2025

Open Access

Imaging Assessment of the Pituitary Gland and Long‐Term Endocrinological Abnormalities in Pediatric Brain Cancer Survivors

Feras Qawasmi MD, Maria Segev MD, Tamer Sobeh MD, Larisa Gorenstein MD, Gadi Abebe-Campino MD, Chen Hoffmann MD, Michal Yalon MD, Dalit Modan-Moses MD, Shai Shrot MD

Pages: 2516-2522 | First Published: 09 December 2024

Editorial

Editorial for “Imaging Assessment of the Pituitary Gland and Long‐Term Endocrinological Abnormalities in Pediatric Brain Cancer Survivors”

Bassem Hiba PhD

Pages: 2523-2524 | First Published: 26 December 2024

Research Article

Abdomen

Open Access

MR Elastography for Classification of Focal Liver Lesions Using Viscoelastic Parameters: A Pilot Study Based on Intrinsic and Extrinsic Activations

Amirhosein Baradaran Najar MSc, Guillaume Gilbert PhD, Elige Karam MD, Anton Volniansky MD, Audrey Fohlen MD, PhD, Maxime Barat MD, PhD, Emmanuel Montagnon PhD, Hélène Castel MD, Jeanne-Marie Giard MD, MPH, Bich N. Nguyen MD, Guy Cloutier PhD, Eng, An Tang MD, MSc, Elijah Van Houten PhD, Eng

Pages: 2525-2540 | First Published: 24 October 2024

Editorial

Editorial for “MR Elastography for Classification of Focal Liver Lesions Using Viscoelastic Parameters: A Pilot Study Based on Intrinsic and Extrinsic Activations”

Jürgen Machann PhD

Pages: 2541-2542 | First Published: 24 October 2024

Research Article

Abdomen

Open Access

Combining Multifrequency Magnetic Resonance Elastography With Automatic Segmentation to Assess Renal Function in Patients With Chronic Kidney Disease

Qiumei Liang MS, Haiwei Lin MS, Junfeng Li MS, Peiyin Luo MS, Ruirui Qi MS, Qiuyi Chen MS, Fanqi Meng BS, Haodong Qin MS, Feifei Qu PhD, Youjia Zeng MD, Wenjing Wang MD, Jiandong Lu MD, Bingsheng Huang PhD, Yueyao Chen MD

Pages: 2543-2555 | First Published: 28 January 2025

Editorial

Editorial for “Combining Multifrequency Magnetic Resonance Elastography With Automatic Segmentation to Assess Renal Function in Patients With Chronic Kidney Disease”

Ilkay S. Idilman, Musturay Karcaaltincaba

Pages: 2556-2557 | First Published: 28 January 2025

Research Article

Abdomen

Evaluating the Potential of Quantitative Susceptibility Mapping for Detecting Iron Deposition of Renal Fibrosis in a Rabbit Model

Tingting Zha MD, Zhiping Zhang MD, Liang Pan MD, Lei Peng MS, Yanan Du MS, Peng Wu MD, Jie Chen MD, Wei Xing MD

Pages: 2558-2569 | First Published: 28 January 2025

Editorial

Editorial for “Evaluating the Potential of Quantitative Susceptibility Mapping for Detecting Iron Deposition of Renal Fibrosis in a Rabbit Model”

Alexey V. Dimov PhD, Martin R. Prince MD, PhD

Pages: 2570-2571 | First Published: 17 February 2025

Research Article

Technical

Open Access

Incorporating Radiologist Knowledge Into MRI Quality Metrics for Machine Learning Using Rank‐Based Ratings

Chenwei Tang MS, Laura B. Eisenmenger MD, Leonardo Rivera-Rivera PhD, Eugene Huo MD, Jacqueline C. Junn MD, Anthony D. Kuner MD, Thekla H. Oechtering MD, Anthony Peret MD, Jitka Starekova MD, Kevin M. Johnson PhD

Pages: 2572-2584 | First Published: 17 December 2024

Editorial

Editorial for “Incorporating Radiologist Knowledge Into MRI Quality Metrics for Machine Learning Using Rank‐Based Ratings”

Yao Lu PhD, Ninghao Chen

Pages: 2585-2586 | First Published: 04 February 2025

Research Article

Cardiac

Open Access

Free‐Breathing Ungated Radial Simultaneous Multi‐Slice Cardiac T1 Mapping

Johnathan V. Le PhD, Jason K. Mendes PhD, Konstantinos Sideris MD, Erik Bieging MD, Spencer Carter MD, Josef Stehlik MD, Edward V. R. DiBella PhD, Ganesh Adluru PhD

Pages: 2587-2600 | First Published: 11 December 2024

Musculoskeletal

Assessment of Age‐Related Microstructure Changes in Thigh Skeletal Muscle Based on Neurite Orientation Dispersion and Density Imaging

Yiou Wang MS, Yiqiong Yang MS, Ziru Qiu MS, Yanjun Chen MD, PhD, Xinru Zhang MS, Qianyi Qiu MS, Yi Yang MS, Qinglin Xie MS, Xinyuan Zhang PhD, Xiaodong Zhang MD, PhD

Pages: 2601-2614 | First Published: 07 December 2024

T2 Clusters Are More Sensitive Than Mean T2 Change to Detect Early and Longitudinal Changes in Anterior Cruciate Ligament Reconstructed and Healthy Knees

Anoosha Pai S MS, Anthony A. Gatti PhD, Marianne S. Black PhD, Katherine A. Young MEd, Arjun D. Desai PhD, Marco Barbieri PhD, Jessica L. Asay MS, Seth L. Sherman MD, Garry E. Gold MD, Feliks Kogan PhD, Brian A. Hargreaves PhD, Akshay S. Chaudhari PhD

Pages: 2615-2629 | First Published: 30 December 2024

Open Access

MRI Radiomics Analysis in the Diagnostic Differentiation of Malignant Soft Tissue Myxoid Sarcomas From Benign Soft Tissue Musculoskeletal Myxomas

Hadas Benhabib MD, MSc, FRCPC, Daniel Brandenberger MD, Katherine Lajkosz MSc, Elizabeth G. Demicco MD, PhD, Kim M. Tsoi MD, PhD, FRCSC, Jay S. Wunder MD, FRCSC, Peter C. Ferguson MD, MSc, FRCSC, Anthony M. Griffin MSc, Ali Naraghi MBBS, MRCP, FRCR, Masoom A. Haider MD, FRCPC, Lawrence M. White MD, FRCPC

Pages: 2630-2641 | First Published: 22 January 2025

Editorial

Editorial for “MRI Radiomics Analysis in the Diagnostic Differentiation of Malignant Soft Tissue Myxoid Sarcomas From Benign Soft Tissue Musculoskeletal Myxomas”

Martin Schwartz PhD

Pages: 2642-2643 | First Published: 26 January 2025

Case Report

Musculoskeletal

Open Access

Induction of Extremely Severe Nausea via Vestibular Activation on a 7 Tesla MRI Scanner

Andrew J. Fagan PhD, Kimberly K. Amrami MD, Robert E. Watson MD, Muhammad A.R. Anjum PhD, Kirk M. Welker MD

Pages: 2644-2647 | First Published: 07 November 2024

LETTER TO THE EDITOR

Three Dimensional Real‐Time MRI for the Comprehensive Evaluation of Wrist Kinematics

Ye Tian, Abhijit J. Chaudhari, Krishna S. Nayak

Pages: 2648-2651 | First Published: 09 April 2025